Types of Collagen and its implications

Courtesy: Prof Nabil Ebraheim, University of Toledo, Ohio, USA
This video describes about various types of collagen.

Collagen is made by fibroblasts & there are about 20 types of collagen which constitutes 20% of our body proteins

• Type 1 collagen accounts for 90% of our body collagen & is associated with primary bone healing. It is found mainly in bones, ligaments, tendon, menisci & annulus fibrosus of intervertebral disc. Osteogenesis imperfecta which is characterized by fragile bone fractures , blue sclera & Ehlers danios syndrome ( loose joints & stretched skin ) are the diseases caused due to defect in type 1 collagen.
• 95% of collagen in cartilage is Type 2 & is seen in secondary bone healing. It has long half life (25 yrs) . It is present in nucleus pulposus of disc & hyaline cartilage of joint. Genetic defect in type 2 collagen cause spondyloepiphyseal dysplasia.
• Type 3 collagen is mainly seen in blood vessels & skin . It’s defect can cause Dupuytren’s contracture. During   healing of tendons, upto 7 days Type 3 collagen is produced & it is replaced by Type 1 until 18 months.
• Defect in Type 10 collagen result in Schmid type Metaphyseal chondrodysplasia. Type 10 collagen is found in fracture callus, growth plate & heterotopic ossification & is associated with calcification of cartilage

Type11 collagen helps in holding collagen lattice together