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Types of Collagen and its implications


Courtesy: Prof Nabil Ebraheim, University of Toledo, Ohio, USA
This video describes about various types of collagen.

Collagen is made by fibroblasts & there are about 20 types of collagen which constitutes 20% of our body proteins

  • Type 1 collagen accounts for 90% of our body collagen & is associated with primary bone healing. It is found mainly in bones, ligaments, tendon, menisci & annulus fibrosus of intervertebral disc. Osteogenesis imperfecta which is characterized by fragile bone fractures , blue sclera & Ehlers danios syndrome ( loose joints & stretched skin ) are the diseases caused due to defect in type 1 collagen.
  • 95% of collagen in cartilage is Type 2 & is seen in secondary bone healing. It has long half life (25 yrs) . It is present in nucleus pulposus of disc & hyaline cartilage of joint. Genetic defect in type 2 collagen cause spondyloepiphyseal dysplasia.
  • Type 3 collagen is mainly seen in blood vessels & skin . It’s defect can cause Dupuytren’s contracture. During   healing of tendons, upto 7 days Type 3 collagen is produced & it is replaced by Type 1 until 18 months.
  • Defect in Type 10 collagen result in Schmid type Metaphyseal chondrodysplasia. Type 10 collagen is found in fracture callus, growth plate & heterotopic ossification & is associated with calcification of cartilage

Type11 collagen helps in holding collagen lattice together
types of collage

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Get Book Kendall’s Muscles: Testing and Function, with Posture and Pain, 6th Edition, transforms this landmark Physical Therapy classic to prepare you for unparalleled clinical success in today’s practice. Timeless coverage of manual muscle testing, evaluation, and treatment meets the latest evidence-based practices, engaging imagery, and dynamic digital resources to create a powerful resource you […]

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