Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis
Mark J Bolland, senior research fellow,1 Alison Avenell, clinical senior lecturer,2 John A Baron, professor,3 Andrew Grey, associate professor,1 Graeme S MacLennan, senior research fellow,2 Greg D Gamble, research fellow,1Ian R Reid, professor1
1Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag
92 019, Auckland 1142, New Zealand, 2Health Services Research Unit, University of Aberdeen, 3Department of Medicine, and Department of Community and Family Medicine, Dartmouth Medical School, NH, USA
BMJ 2010;341:c3691 doi:10.1136/bmj.c3691
Conclusions: Calcium supplements (without coadministered vitamin D) are associated with an increased risk of myocardial infarction. As calcium supplements are widely used these modest increases in risk of cardiovascular disease might translate into a large burden of disease in the population. A reassessment of the role of calcium supplements in the management of osteoporosis is warranted.
Full text: http://www.bmj.com/cgi/content/full/341/jul29_1/c3691
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